Discovery of the human genome sequence in the public and private databases
نویسندگان
چکیده
Genomes: Much heat has been generated in discussions about the key human genome sequence databases, generated by the Human Genome Project and Celera, and what specific features each offers genome researchers. Stephen W. Scherer and Joseph Cheung, who are intense users of both, offer a personal assessment of the developing contents.
منابع مشابه
Single Nucleotide Polymorphisms and Association Studies: A Few Critical Points
Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...
متن کاملI-49: Human Y Chromosome ProteomeProject
The success of the Human Genome Project (HGP) has provided a blueprint for the approximately 20,000 gene-encoded proteins potentially active in all of the hundreds of cell types that make up the human body. Yet we still have limited knowledge about a majority of the gene-encoded proteins which are the “building blocks of life” and “cellular machinery”. It is estimated that for nearly half of th...
متن کاملA novel DNA sequence database for analyzing human demographic history.
While there are now extensive databases of human genomic sequences from both private and public efforts to catalog human nucleotide variation, there are very few large-scale surveys designed for the purpose of analyzing human population history. Demographic inference from patterns of SNP variation in current large public databases is complicated by ascertainment biases associated with SNP disco...
متن کاملProtein Databases
Proteins are sources of many peptides with diverse biological activity. Some of them are considered as valuable components of foods and drug targets with desired and designed biological activity. We are now entering an era rich in biological data in which the field of bioinformatics is poised to exploit this information in increasingly powerful ways. There are currently many databases all over ...
متن کاملنقش امیکس ها در تحقیقات بالینی- دارویی
Completion of the human genome project revealed that the molecular mechanisms of cellular responses to different situations cannot be predicted from the sequence of their genes. Hence, most biological researches are focused on the roles of proteins which are much more challenging tasks. Omics technologies, instead of analyzing individual components of an organism by conventional biochemical met...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 11 شماره
صفحات -
تاریخ انتشار 2001